Detalhe da pesquisa
1.
Nascent Aß42 Fibrillization in Synaptic Endosomes Precedes Plaque Formation in a Mouse Model of Alzheimer's-like ß-Amyloidosis.
J Neurosci
; 43(50): 8812-8824, 2023 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37884349
2.
A new class of monoclonal Aß antibodies selectively targets and triggers deposition of Aß protofibrils.
J Neurochem
; 165(6): 860-873, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37002186
3.
The intricate biophysical puzzle of caspase-1 activation.
Arch Biochem Biophys
; 699: 108753, 2021 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33453207
4.
Disentangling aggregation-prone proteins: a new method for isolating α-synuclein species: An Editorial Highlight for "A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α-synuclein research" on page 103.
J Neurochem
; 153(1): 7-9, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32037541
5.
Inflammatory mechanisms in neurodegeneration.
J Neurochem
; 149(5): 562-581, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30702751
6.
APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease.
J Neurosci
; 36(32): 8471-86, 2016 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27511018
7.
The conformational epitope for a new Aß42 protofibril-selective antibody partially overlaps with the peptide N-terminal region.
J Neurochem
; 143(6): 736-749, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28881033
8.
Aß40 has a subtle effect on Aß42 protofibril formation, but to a lesser degree than Aß42 concentration, in Aß42/Aß40 mixtures.
Arch Biochem Biophys
; 597: 1-11, 2016 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27013205
9.
Biophysical comparison of soluble amyloid-ß(1-42) protofibrils, oligomers, and protofilaments.
Biochemistry
; 54(13): 2193-204, 2015 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25756466
10.
Amyloid-ß(1-42) protofibrils stimulate a quantum of secreted IL-1ß despite significant intracellular IL-1ß accumulation in microglia.
Biochim Biophys Acta
; 1842(11): 2276-85, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25125050
11.
Stability of early-stage amyloid-ß(1-42) aggregation species.
Biochim Biophys Acta
; 1834(1): 65-70, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22944394
12.
CD47 does not mediate amyloid-ß(1-42) protofibril-stimulated microglial cytokine release.
Biochem Biophys Res Commun
; 454(1): 239-44, 2014 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25451248
13.
Development of ß-sheet structure in Aß aggregation intermediates diminishes exposed hydrophobic surface area and enhances proinflammatory activity.
Biochim Biophys Acta Proteins Proteom
; 1870(9): 140817, 2022 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35905824
14.
Development of a Simple and Effective Lipid-A Antagonist Based on Computational Prediction.
ACS Infect Dis
; 8(6): 1171-1178, 2022 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35612826
15.
Substituted tryptophans at amyloid-ß(1-40) residues 19 and 20 experience different environments after fibril formation.
Arch Biochem Biophys
; 514(1-2): 27-32, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21843498
16.
Inhibition of matrix metalloproteinase-9 secretion by dimethyl sulfoxide and cyclic adenosine monophosphate in human monocytes.
World J Biol Chem
; 12(1): 1-14, 2021 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33552397
17.
Expression of NLRP3 inflammasome proteins in ExpiCHO-S mammalian cells reveals oligomerization properties that are highly sensitive to solution conditions.
Biotechnol Prog
; 37(4): e3153, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33811748
18.
Probing the amyloid-beta(1-40) fibril environment with substituted tryptophan residues.
Arch Biochem Biophys
; 494(2): 192-7, 2010 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19995549
19.
Author Correction: Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.
Nat Med
; 26(6): 981, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32409732
20.
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.
Nat Med
; 26(1): 131-142, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31932797